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Company announcements and news from our partners.

MAPLE trial endpoint: PhenoBiome prebiotic raises gut microbial diversity, measured on Perseus Biomics’ DynaMAP platform

PALM SPRINGS, CA, UNITED STATES, September 29, 2026 / EINPresswire.com / — PhenoBiome today reported results from its MAPLE clinical trial, an eight-week study of a personalized nutritional (prebiotic) supplement in adults, run in collaboration with Perseus Biomics using the DynaMAP microbiome-profiling platform. The trial met its primary microbiome endpoint: species-level Shannon diversity rose by 0.55 points (from 4.91 to 5.46; p = 0.010) across the twelve completers, with eight of twelve gaining diversity against their own baseline.

University of Roehampton celebrates national recognition for innovative addiction recovery projects

Dr Adele Costabile (School of Health and Life Sciences) with Back to Balance Test This research will validate a gut microbiome-based digital intervention that supports alcohol addiction recovery by improving gut health, mental wellbeing, and resilience against relapse.  

PhenoBiome Welcomes New Leadership and Validates Breakthrough Microbiome Modulation

PALM SPRINGS, CA, UNITED STATES, March 25, 2025 /EINPresswire.com / PhenoBiome, Inc., a pioneering leader in personalized microbiome solutions, today announced the appointment of Brian Russon as Chief Executive Officer (CEO) and Kait Mikes as Chief Operating Officer (COO).   

PhenoBiome launches human gut microbiome assay with Genetic Direction

SAN FRANCISCO, Sept. 23, 2021 /PRNewswire/ — PhenoBiome today announced it will launch its first human gut microbiome assay through Genetic Direction, a Dallas-based distributor of genetics-based health management programs. Clinical Enterprise, Inc., a Eurofins Scientific company, will process the assays in its CLIA- and CAP-certified laboratory. 

Key Papers

Selected papers describing PhenoBiome’s technology and its application to the human gut microbiome.

2024 · Technology & applications

Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition

Nature Microbiology. 2024 Apr; 9(4):922-937.

View authors

Chang HW, Lee EM, Wang Y, Zhou C, Pruss KM, Henrissat S, Chen RY, Kao C, Hibberd MC, Lynn HM, Webber DM, Crane M, Cheng J, Rodionov DA, Arzamasov AA, Castillo JJ, Couture G, Chen Y, Balcazo NP Jr, Lebrilla CB, Terrapon N, Henrissat B, Ilkayeva O, Muehlbauer MJ, Newgard CB, Mostafa I, Das S, Mahfuz M, Osterman AL, Barratt MJ, Ahmed T, Gordon JI

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2024 · Technology & applications

Bioactive glycans in a microbiome-directed food for children with malnutrition

Nature. 2024 Jan; 625(7993):157-165.

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Hibberd MC, Webber DM, Rodionov DA, Henrissat S, Chen RY, Zhou C, Lynn HM, Wang Y, Chang HW, Lee EM, Lelwala-Guruge J, Kazanov MD, Arzamasov AA, Leyn SA, Lombard V, Terrapon N, Henrissat B, Castillo JJ, Couture G, Bacalzo NP Jr, Chen Y, Lebrilla CB, Mostafa I, Das S, Mahfuz M, Barratt MJ, Osterman AL, Ahmed T, Gordon JI

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Extended Publications

Publications on PhenoBiome’s technology and its applications, listed newest first.

Publication legend

D Methodology — Development or description of computational methods, including genomics-based reconstruction of metabolic pathways and regulatory mechanisms.

A Application — Use of the methodology to address a biological or medical problem.

V Experimental validation — Experimental testing of bioinformatics-based predictions.

Where shown, letter badges retain the original publication classifications.

2026

Microbiome · Preprint

Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity

bioRxiv [Preprint]. 2026 May 11. DOI: 10.64898/2026.05.06.723300.
View authors

Olea XD, Beede K, Pereira G, Scott D, Petucci C, Martens E, Rodionov DA, Shah A, Martinez MP, Kim H, Sharma AK, Martin A, Zhang T, Faries MB, Hamid O, Devkota S, Osterman AL, Knott S, Voest EE, Ajami NJ, Wargo J, Ramer-Tait AE, Ronai ZA

2025

2024

Microbiome

Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition

Nature Microbiology. 2024 Apr; 9(4):922-937.
View authors

Chang HW, Lee EM, Wang Y, Zhou C, Pruss KM, Henrissat S, Chen RY, Kao C, Hibberd MC, Lynn HM, Webber DM, Crane M, Cheng J, Rodionov DA, Arzamasov AA, Castillo JJ, Couture G, Chen Y, Balcazo NP Jr, Lebrilla CB, Terrapon N, Henrissat B, Ilkayeva O, Muehlbauer MJ, Newgard CB, Mostafa I, Das S, Mahfuz M, Osterman AL, Barratt MJ, Ahmed T, Gordon JI

Microbiome

Bioactive glycans in a microbiome-directed food for children with malnutrition

Nature. 2024 Jan; 625(7993):157-165.
View authors

Hibberd MC, Webber DM, Rodionov DA, Henrissat S, Chen RY, Zhou C, Lynn HM, Wang Y, Chang HW, Lee EM, Lelwala-Guruge J, Kazanov MD, Arzamasov AA, Leyn SA, Lombard V, Terrapon N, Henrissat B, Castillo JJ, Couture G, Bacalzo NP Jr, Chen Y, Lebrilla CB, Mostafa I, Das S, Mahfuz M, Barratt MJ, Osterman AL, Ahmed T, Gordon JI

2023

2022

2021

Microbiome D

Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

Nature. 2021;595(7865):91-95.
View authors

Delannoy-Bruno O, Desai C, Raman AS, Chen RY, Hibberd MC, Cheng J, Han N, Castillo JJ, Couture G, Lebrilla CB, Barve RA, Lombard V, Henrissat B, Leyn SA, Rodionov DA, Osterman AL, Hayashi DK, Meynier A, Vinoy S, Kirbach K, Wilmot T, Heath AC, Klein S, Barratt MJ, Gordon JI.

2020

Microbiome A

Duodenal Microbiota in Stunted Undernourished Children with Enteropathy

N Engl J Med. 2020 Jul 23;383(4):321-333
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Chen RY, Kung VL, Das S, Hossain MS, Hibberd MC, Guruge J, Mahfuz M, Begum SMKN, Rahman MM, Fahim SM, Gazi MA, Haque R, Sarker SA, Mazumder RN, Di Luccia B, Ahsan K, Kennedy E, Santiago-Borges J, Rodionov DA, Leyn SA, Osterman AL, Barratt MJ, Ahmed T, Gordon JI

2019

Microbiome A

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Science. 2019 Jul 12;365(6449):eaau4732
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Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Kung VL, Cheng J, Chen RY, Subramanian S, Cowardin CA, Meier MF, O'Donnell D, Talcott M, Spears LD, Semenkovich CF, Henrissat B, Giannone RJ, Hettich RL, Ilkayeva O, Muehlbauer M, Newgard CB, Sawyer C, Head RD, Rodionov DA, Arzamasov AA, Leyn SA, Osterman AL, Hossain MI, Islam M, Choudhury N, Sarker SA, Huq S, Mahmud I, Mostafa I, Mahfuz M, Barratt MJ, Ahmed T, Gordon JI

2018

2017

2016

2015

2014

2013

2012

2010

2008

Microbiome

The RAST Server: rapid annotations using subsystems technology

BMC Genomics. 2008 Feb 8;9:75. doi: 10.1186/1471-2164-9-75.
View authors

Aziz RK, Bartels D, Best AA, DeJongh M, Disz T, Edwards RA, Formsma K, Gerdes S, Glass EM, Kubal M, Meyer F, Olsen GJ, Olson R, Osterman AL, Overbeek RA, McNeil LK, Paarmann D, Paczian T, Parrello B, Pusch GD, Reich C, Stevens R, Vassieva O, Vonstein V, Wilke A, Zagnitko O

2007

2006

2005

Microbiome D

The subsystems approach to genome annotation and its use in the project to annotate 1000 genomes

Nucleic Acids Res. 2005 Oct 7;33(17):5691-702
View authors

Overbeek R, Begley T, Butler RM, Choudhuri JV, Chuang HY, Cohoon M, de Crécy-Lagard V, Diaz N, Disz T, Edwards R, Fonstein M, Frank ED, Gerdes S, Glass EM, Goesmann A, Hanson A, Iwata-Reuyl D, Jensen R, Jamshidi N, Krause L, Kubal M, Larsen N, Linke B, McHardy AC, Meyer F, Neuweger H, Olsen G, Olson R, Osterman A, Portnoy V, Pusch GD, Rodionov DA, Rückert C, Steiner J, Stevens R, Thiele I, Vassieva O, Ye Y, Zagnitko O, Vonstein V

2004

2003

2002

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